Description

Sphos Palladacycle Gen. 4 is a highly active, third-generation Buchwald precatalyst designed for efficient cross-coupling reactions. This catalyst matters for its excellent stability, broad functional group tolerance, and high activity under mild conditions, enabling streamlined synthesis in complex molecule construction. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable and scalable palladium catalysis.

Application

• Pharmaceutical Intermediate Synthesis: Key for Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling in API development.
• Agrochemical Manufacturing: Used in the synthesis of complex, bioactive molecules for crop protection agents.
• Materials Science Research: Facilitates the construction of conjugated polymers and organic electronic materials.
• Academic & Process R&D: A preferred precatalyst for method development and scaling up C-N and C-C bond-forming reactions.
• Fine Chemical Production: Enables the efficient and selective synthesis of specialty chemicals and complex aromatics.

Basic Information

Product Name	Sphos Palladacycle Gen. 4
CAS No.	1599466-87-1
Molecular Formula	C₃₁H₄₀ClNO₂PPdS
Molecular Weight	675.55 g/mol
Synonyms	Chlorido[2-(dicyclohexylphosphino)-2',6'-bis(propan-2-yloxy)-1,1'-biphenyl][2-(methylamino)phenyl]palladium; [2-(2-Aminophenyl)phenyl]chloropalladium(II) SPhos adduct; SPhos Pd G3; Pd-PEPPSI SPhos; Buchwald Palladacycle SPhos Gen. 4; Palladium SPhos Precatalyst; Pd-SPhos Cyclometallated Catalyst
EINECS	Contact for details

Quality Control

Our Sphos Palladacycle Gen. 4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ³¹P), HPLC for purity, and ICP-MS for heavy metal content, to ensure compliance with rigorous standards for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. Keep the container in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Pd Content (ICP-MS)	14.0 - 16.0 %
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.