Description

Brettphos Pd G4 CAS NO 1599466-83-7 is a highly active, third-generation palladium catalyst ligand, specifically designed for challenging cross-coupling reactions. Its value lies in enabling efficient and selective transformations, particularly for the synthesis of complex pharmaceutical intermediates and advanced materials. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require robust catalytic systems for demanding synthetic protocols.

Application

• Buchwald-Hartwig Amination: A premier ligand for C–N bond formation, especially with sterically hindered or electronically deactivated aryl chlorides and tosylates.
• Suzuki-Miyaura Cross-Coupling: Facilitates the coupling of aryl/heteroaryl chlorides with boronic acids under mild conditions.
• C–O and C–S Bond Formation: Effective in cross-couplings to create aryl ethers and thioethers.
• Pharmaceutical Intermediate Synthesis: Critical for constructing complex, nitrogen-containing scaffolds in active pharmaceutical ingredient (API) development.
• Agrochemical Compound Manufacturing: Used in the synthesis of novel herbicides, fungicides, and insecticides.
• Material Science Research: Applied in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Process Chemistry & Scale-up: Valued for its stability and performance in moving reactions from lab-scale to pilot plant and production.

Basic Information

Product Name	Brettphos Pd G4
CAS No.	1599466-83-7
Molecular Formula	C₄₁H₅₆Cl₂NOP₂Pd
Molecular Weight	794.14 g/mol
Synonyms	BrettPhos Pd G4; Chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); Pd-G4(BrettPhos); BrettPhos Palladacycle Gen. 4; Palladium(II) BrettPhos Chloride Complex; Third-Generation BrettPhos Precatalyst; CataCXium® P Pd G4 (analogous); t-Bu BrettPhos Pd G4 (common variant)
EINECS	Contact for details

Quality Control

Our Brettphos Pd G4 is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by NMR, HPLC, and elemental analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange-brown crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Pd Content	12.0 - 14.0 %
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.