Description

(S)-Methyl-6-Bromo-1-(1-Hydroxy-3-Methylbutan-2-Yl)-7-Methoxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is a high-purity, chiral quinoline derivative serving as a critical synthetic intermediate in advanced pharmaceutical research and development. This compound is valued for its complex molecular architecture, which provides a versatile scaffold for constructing novel active pharmaceutical ingredients (APIs) with specific stereochemistry. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel quinoline-based drug candidates, particularly in oncology and anti-infective research.
• Chiral Synthesis: Utilized in asymmetric synthesis to introduce the (S)-configured stereocenter into complex molecules, ensuring the desired biological activity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• Process Chemistry: Serves as a defined starting material or advanced intermediate in the scale-up and optimization of API manufacturing processes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.
• Academic Research: Used in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	(S)-Methyl-6-Bromo-1-(1-Hydroxy-3-Methylbutan-2-Yl)-7-Methoxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate
CAS No.	1598387-95-1
Molecular Formula	C₁₇H₂₀BrNO₅
Molecular Weight	398.25 g/mol
Synonyms	(S)-Methyl 6-bromo-1-((S)-1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate; (S)-6-Bromo-1-((S)-1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid methyl ester; (S)-Methyl 6-bromo-1-(1-hydroxy-3-methyl-2-butyl)-7-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate; Quinoline-3-carboxylic acid, 6-bromo-1,4-dihydro-1-(1-hydroxy-3-methyl-2-butyl)-7-methoxy-4-oxo-, methyl ester, (S)-; CAS 1598387-95-1; BRD-K4477 intermediate; Chiral bromo-methoxy quinoline ester
EINECS	Contact for details

Quality Control

Our (S)-Methyl-6-Bromo-1-(1-Hydroxy-3-Methylbutan-2-Yl)-7-Methoxy-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.