Description

Methyltetrazine-Amine Hydrochloride CAS NO 1596117-29-1 is a high-value, functionalized tetrazine derivative used as a critical building block in advanced chemical synthesis. Its primary value lies in its role as a bioorthogonal reagent, enabling highly specific and rapid conjugation reactions under mild physiological conditions. This compound is essential for researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and materials science, particularly for creating antibody-drug conjugates (ADCs), diagnostic probes, and functional polymers.

Application

• Bioorthogonal Chemistry & Bioconjugation: A key reagent for Inverse Electron Demand Diels-Alder (IEDDA) click chemistry with trans-cyclooctene (TCO) for labeling biomolecules.
• Antibody-Drug Conjugate (ADC) Development: Used to create stable, site-specific linkages between cytotoxic payloads and monoclonal antibodies for targeted cancer therapies.
• Diagnostic Probe & Imaging Agent Synthesis: Facilitates the attachment of fluorophores, radiolabels, or other reporter molecules to targeting vectors for in vitro and in vivo imaging.
• Polymer & Materials Science: Serves as a functional monomer or cross-linker for synthesizing smart polymers, hydrogels, and surface-modified materials with responsive properties.
• Chemical Biology & Proteomics: Enables the study of protein function, localization, and interactions through selective labeling strategies in live cells.
• Preclinical & Pharmaceutical Research: A vital intermediate in the discovery and development stages of novel therapeutic agents and delivery systems.

Basic Information

Item	Detail
Product Name	Methyltetrazine-Amine Hydrochloride
CAS No.	1596117-29-1
Molecular Formula	C5H9N5·HCl
Molecular Weight	191.62 g/mol (Free base: 155.16 g/mol)
Synonyms	5-Methyltetrazin-2-amine hydrochloride; 2-Amino-5-methyl-1,2,4,5-tetrazine hydrochloride; Methyltetrazine amine HCl; 5-Methyl-1,2,4,5-tetrazin-2-amine hydrochloride; TETRAZINE-AMINE, 5-METHYL-, HYDROCHLORIDE; Me-Tz-NH2·HCl; Methyl-Tz-Amine HCl
EINECS	Contact for details

Quality Control

Our Methyltetrazine-Amine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive bioorthogonal applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development and cGMP-grade production to meet the stringent requirements of pharmaceutical and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (H-NMR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.