Description

2-Amino-m-Tolyl Triflate, 2-Methyl-6-{[(Trifluoromethyl)Sulphonyl]Oxy}Aniline is a specialized triflate-protected aniline derivative, serving as a critical high-purity building block in advanced organic synthesis. Its value lies in providing a reactive handle for cross-coupling reactions while protecting the amine functionality, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and complex fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system and oncological pathways.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with tailored properties.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Material Science Research: Monomer or intermediate for synthesizing functional polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: Serves as a substrate in Buchwald-Hartwig amination, Suzuki-Miyaura, and other palladium-catalyzed coupling reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	2-Amino-m-Tolyl Triflate, 2-Methyl-6-{[(Trifluoromethyl)Sulphonyl]Oxy}Aniline
CAS No.	1589523-29-4
Molecular Formula	C8H8F3NO3S
Molecular Weight	255.21 g/mol
Synonyms	2-Methyl-6-{[(trifluoromethyl)sulfonyl]oxy}aniline; 2-Amino-3-methylphenyl trifluoromethanesulfonate; 6-Amino-2-methylphenyl triflate; 2-Methyl-6-(trifluoromethanesulfonyloxy)aniline; 3-Methyl-2-aminophenyl triflate; 2-Amino-m-cresyl triflate; Aniline, 2-methyl-6-[(trifluoromethyl)sulfonyl]oxy]-; 1589523-29-4
EINECS	Contact for details

Quality Control

Our 2-Amino-m-Tolyl Triflate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.