Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-Methoxypropanoic Acid is a specialized, high-purity amino acid derivative designed for advanced chemical synthesis. This compound matters as a critical building block for the controlled introduction of a protected, methylated amino acid moiety into complex molecular architectures. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive compounds, where precise stereochemistry and functional group protection are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the sequential assembly of custom peptide sequences.
• Peptidomimetic Drug Discovery: Used to incorporate non-natural amino acid structures into lead compounds to enhance metabolic stability and binding affinity.
• Bioconjugation and Linker Chemistry: Serves as a versatile intermediate for creating chemically defined conjugates between biomolecules and other functional entities.
• Chemical Biology Research: Employed in the synthesis of probes and tools for studying enzyme mechanisms and protein-protein interactions.
• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) and candidates.
• Academic & Industrial R&D: For fundamental research in organic synthesis and the development of new synthetic methodologies.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-Methoxypropanoic Acid
CAS No.	1569103-64-5
Molecular Formula	C20H21NO5
Molecular Weight	355.39 g/mol
Synonyms	Fmoc-N-Me-Ser(OMe)-OH; Fmoc-N-methyl-O-methyl-L-serine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-methyl-L-serine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]-3-methoxypropanoic acid; Nα-Fmoc-Nα-methyl-O-methyl-L-serine; Fmoc-N-Me-Ser(Me)-OH; N-Fmoc-N-methyl-O-methylserine; L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-, methyl ether
EINECS	Contact for details

Quality Control

Our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-Methoxypropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring compliance with research and development grade standards. Certificates of Analysis (COA) detailing specific batch results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.