Description

(1R,2R)-Methyl 5-Methyl-2-Oxospiro[Cyclopropane-1,3-Indoline]-2-Carboxylate (Wx145584) is a high-purity, chiral spirocyclic oxindole derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and a versatile chiral building block for the development of novel bioactive molecules. It is primarily utilized by research institutions and industrial R&D departments focused on medicinal chemistry, particularly in the synthesis of complex molecules targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, especially those with spirocyclic architectures.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Asymmetric Synthesis: Employed as a building block in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and protein functions.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: A valuable compound for methodological studies in organic synthesis and catalysis at universities and research institutes.

Basic Information

Product Name	(1R,2R)-Methyl 5-Methyl-2-Oxospiro[Cyclopropane-1,3-Indoline]-2-Carboxylate (Wx145584)
CAS No.	1567390-14-0
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	Methyl (1R,2R)-5-methyl-2-oxospiro[cyclopropane-1,3'-indoline]-2'-carboxylate; Wx145584; (1R,2R)-5-Methyl-2-oxospiro[cyclopropane-1,3-indoline]-2-carboxylic acid methyl ester; (1R,2R)-Methyl 5-methyl-2-oxo-1-azaspiro[2.5]oct-3-ene-3-carboxylate; Spiro[cyclopropane-1,3'-indoline]-2'-carboxylic acid, 5-methyl-2-oxo-, methyl ester, (1R,2R)-; Chiral spiro-oxindole ester.
EINECS	Contact for details

Quality Control

Our (1R,2R)-Methyl 5-Methyl-2-Oxospiro[Cyclopropane-1,3-Indoline]-2-Carboxylate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure identity, purity, and enantiomeric excess meet stringent specifications. Certificates of Analysis (COA) detailing all test results are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled and stored accordingly to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.