Description

2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile, 2-[(2R)-2-Amino-2-(3-Hydroxytricyclo[3.3.1.13,7]Dec-1-Yl)Acetyl]-, (1S,3S,5S)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) targeting neurological and metabolic disorders. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of novel therapeutics. The precise stereochemistry and functional groups make it a valuable building block for modern drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel central nervous system (CNS) and antiviral drug candidates.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and the commercial-scale production of complex, high-value APIs.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.
• Academic Research: Employed in university and institutional labs for studying novel synthetic methodologies and bioorganic chemistry.

Basic Information

Product Name	2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile, 2-[(2R)-2-Amino-2-(3-Hydroxytricyclo[3.3.1.13,7]Dec-1-Yl)Acetyl]-, (1S,3S,5S)-
CAS No.	1564265-93-5
Molecular Formula	C18H25N3O2
Molecular Weight	315.41 g/mol
Synonyms	(1S,3S,5S)-2-[(2R)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-, (1S,3S,5S)-; (1S,3S,5S)-2-((R)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile; Advanced Saxagliptin Intermediate; Adamantyl-containing azabicyclo intermediate; Bicyclic nitrile pharmaceutical building block.
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Our quality control includes rigorous analytical testing via HPLC, GC, NMR, and MS to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with ICH guidelines and can supply material suitable for use in cGMP environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.