Description

2,4-Difluoro-5-Methylcinnamic Acid is a high-purity fluorinated cinnamic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and the methyl group, which are essential for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators, where the difluoro-methyl motif can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialized polymers and advanced organic materials with tailored properties.
• Liquid Crystal & OLED Materials: Employed in the research and production of fluorinated components for electronic displays and lighting technologies.
• Chemical Biology Probe: Utilized as a building block for creating molecular probes and tags used in biochemical and diagnostic research.

Basic Information

Product Name	2,4-Difluoro-5-Methylcinnamic Acid
CAS No.	1562311-33-4
Molecular Formula	C₁₀H₈F₂O₂
Molecular Weight	198.17 g/mol
Synonyms	(2E)-3-(2,4-Difluoro-5-methylphenyl)prop-2-enoic acid; 5-Methyl-2,4-difluorocinnamic acid; trans-2,4-Difluoro-5-methylcinnamic acid; (E)-3-(2,4-Difluoro-5-methylphenyl)acrylic acid; 2,4-Difluoro-5-methyl-trans-cinnamic acid; α,2,4-Trifluoro-5-methylcinnamic acid (common misnomer); DFMCA
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-5-Methylcinnamic Acid is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with exacting customer specifications and industry standards. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request and are essential for regulatory filings in pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.