Description

3,4-Difluoro-2-Methoxyphenylacetic Acid is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its unique molecular structure, which incorporates both fluorine atoms and a methoxy group on the phenylacetic acid core, enabling precise modifications to the physicochemical properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where it serves as a critical intermediate.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the difluoro-methoxy motif can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to influence molecular polarity and packing.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with tailored thermal, chemical, or surface properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, structure-activity relationship (SAR) studies, and exploring new fluorination chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API (Active Pharmaceutical Ingredient) batches.

Basic Information

Product Name	3,4-Difluoro-2-Methoxyphenylacetic Acid
CAS No.	1558274-26-2
Molecular Formula	C9H8F2O3
Molecular Weight	202.16 g/mol
Synonyms	2-(3,4-Difluoro-2-methoxyphenyl)acetic Acid; (3,4-Difluoro-2-methoxyphenyl)acetic Acid; 3,4-Difluoro-2-methoxybenzeneacetic Acid; 2-Methoxy-3,4-difluorophenylacetic Acid; α-(3,4-Difluoro-2-methoxyphenyl)acetic Acid; DFMPAA; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-2-Methoxyphenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our commitment to quality assurance and supply chain reliability makes us a trusted partner for critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible. Keep away from strong oxidizers, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.