Description

1,1-Dichloro-2-Oxo-6-Azaspiro[3.4]Octane-6-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and dichloro-substituted structure. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures essential for drug discovery and development. It is primarily sought by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or warheads in targeted protein degradation platforms.
• CNS Drug Discovery: Employed in the research and development of pharmaceuticals targeting neurological disorders.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic and heterocyclic chemistry.

Basic Information

Product Name	1,1-Dichloro-2-Oxo-6-Azaspiro[3.4]Octane-6-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	1558037-99-2
Molecular Formula	C12H17Cl2NO3
Molecular Weight	294.18 g/mol
Synonyms	tert-Butyl 1,1-dichloro-2-oxo-6-azaspiro[3.4]octane-6-carboxylate; 6-(tert-Butoxycarbonyl)-1,1-dichloro-6-azaspiro[3.4]octan-2-one; 1,1-Dichloro-2-oxo-6-azaspiro[3.4]octane-6-carboxylic acid tert-butyl ester; Boc-Protected 1,1-Dichloro-6-azaspiro[3.4]octan-2-one; Spirocyclic Dichloro Lactam Ester
EINECS	Contact for details

Quality Control

Our 1,1-Dichloro-2-Oxo-6-Azaspiro[3.4]Octane-6-Carboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.