Description

8-Chloro-4,6-Dimethyl-5H,6H-Benzo[C]2,7-Naphthyridin-5-One is a high-purity, advanced pharmaceutical intermediate belonging to the naphthyridine class of heterocyclic compounds. This specialized chemical serves as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, particularly within oncology and antiviral research programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules and investigational new drugs (INDs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Oncology Drug Development: Employed in the research and synthesis of potential kinase inhibitors and other targeted cancer therapies.
• Antiviral Agent Synthesis: Serves as a building block for creating novel compounds with potential activity against viral pathogens.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and protein functions.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	8-Chloro-4,6-Dimethyl-5H,6H-Benzo[C]2,7-Naphthyridin-5-One
CAS No.	1551407-49-8
Molecular Formula	C₁₄H₁₁ClN₂O
Molecular Weight	258.70 g/mol
Synonyms	8-Chloro-4,6-dimethyl-5H,6H-benzo[c][2,7]naphthyridin-5-one; 8-Chloro-4,6-dimethylbenzo[c][2,7]naphthyridin-5(6H)-one; Benzo[c][2,7]naphthyridin-5-one, 8-chloro-4,6-dihydro-4,6-dimethyl-; 1551407-49-8; 8-Chloro-4,6-dimethyl-5,6-dihydrobenzo[c][2,7]naphthyridin-5-one
EINECS	Contact for details

Quality Control

Our 8-Chloro-4,6-Dimethyl-5H,6H-Benzo[C]2,7-Naphthyridin-5-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate production. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.