Description

(R)-tert-Butyl 3-Methyl-1-Oxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate is a high-value, chiral spirocyclic building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, particularly for targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical and biotechnology companies for the creation of novel active pharmaceutical ingredients (APIs). Its defined stereochemistry and spirocyclic scaffold offer unique advantages for modulating biological activity and improving drug-like properties.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, especially in neuroscience and oncology.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and route development for potential APIs.
• Spirocyclic Compound Library Synthesis: Integral for constructing diverse screening libraries focused on spirocyclic chemotypes.
• Asymmetric Synthesis: Employed in chiral pool synthesis due to its pre-defined (R)-configuration at a stereogenic center.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use as a component in bifunctional molecules designed for targeted protein degradation.

Basic Information

Product Name	(R)-tert-Butyl 3-Methyl-1-Oxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate
CAS No.	1548290-30-7
Molecular Formula	C14H24N2O3
Molecular Weight	268.35 g/mol
Synonyms	8-Boc-3-methyl-1-oxo-2,8-diazaspiro[4.5]decan-2-ium-2-ide; (R)-3-Methyl-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; tert-Butyl (R)-3-methyl-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate; (R)-8-(tert-Butoxycarbonyl)-3-methyl-2,8-diazaspiro[4.5]decan-1-one; 2,8-Diazaspiro[4.5]decan-1-one, 8-(1,1-dimethylethyl) 3-methyl-, (3R)-; BOC-protected spirocyclic lactam; (R)-Boc-3-methyl-2,8-diazaspiro[4.5]decan-1-one
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-Methyl-1-Oxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity, NMR for structural confirmation, and assays for chemical purity and residual solvents. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.