Description

[1,3-Bis(2,6-Di-I-Propylphenyl)Imidazolidin-2-Ylidene)(Tricyclohexylphosphine)-(2-Oxobenzylidene)Ruthenium(Ii) Chloride Latmet Sipr is a highly specialized, second-generation Grubbs-Hoveyda type ruthenium-based olefin metathesis catalyst. This compound is valued for its exceptional thermal stability and functional group tolerance, enabling complex synthetic transformations under mild conditions. It is a critical reagent for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for ring-closing metathesis (RCM), cross metathesis (CM), and ring-opening metathesis polymerization (ROMP).

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for constructing complex macrocyclic and heterocyclic ring systems in active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of novel, complex molecules for crop protection agents and pesticides.
• Polymer & Material Science: Enables the production of specialty polymers via ROMP for applications in coatings, elastomers, and self-healing materials.
• Fine Chemical & Specialty Chemical Production: Facilitates efficient, scalable routes to high-value fragrance, flavor, and performance chemical intermediates.
• Academic & Industrial R&D: An essential tool for methodology development and exploring new chemical space in organic synthesis laboratories.
• Process Chemistry Optimization: Employed for developing cleaner, more atom-economical, and cost-effective manufacturing routes.

Basic Information

Item	Details
Product Name	[1,3-Bis(2,6-Di-I-Propylphenyl)Imidazolidin-2-Ylidene)(Tricyclohexylphosphine)-(2-Oxobenzylidene)Ruthenium(Ii) Chloride Latmet Sipr
CAS No.	1544328-59-7
Molecular Formula	C54H78ClN2OPRu
Molecular Weight	936.61 g/mol
Synonyms	Grubbs-Hoveyda II Catalyst; Hoveyda-Grubbs Catalyst 2nd Generation; (1,3-Bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene)(tricyclohexylphosphine)(2-oxobenzylidene)ruthenium(II) chloride; Latmet Sipr; Ru Catalyst for Olefin Metathesis; HG II Catalyst; Zhan Catalyst 1B; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our ruthenium metathesis catalyst is produced and tested under strict quality management protocols. We guarantee high purity and consistent catalytic performance, with specifications typically covering identity, assay, and residual solvent content. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the results from advanced analytical techniques including NMR and HPLC. Our quality systems are designed to support cGMP and ISO standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. This material is moisture-sensitive (hygroscopic) and easily oxidized; ensure containers are sealed immediately after use and handled in a controlled, dry environment.

Specification

Item	Specification
Appearance	Purple to brown crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.