Description

n-Hydroxy Ropinirole Hcl CAS NO 1542267-72-0 is a high-purity pharmaceutical intermediate and reference standard, specifically a hydroxylated derivative of the dopamine agonist Ropinirole. This compound is critical for advanced research and development in neuropharmacology, serving as a key building block or analytical marker. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and analytical laboratories engaged in the synthesis, metabolism studies, and quality control of novel therapeutic agents targeting neurological disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel dopamine agonist analogs and prodrugs.
• Metabolite Reference Standard: Used as an analytical standard in LC-MS, HPLC, and GC-MS for the identification and quantification of Ropinirole metabolites in pharmacokinetic and bioequivalence studies.
• Pharmacological Research: Employed in vitro and in vivo studies to investigate the structure-activity relationship (SAR) and metabolic pathways of dopaminergic compounds.
• Impurity Profiling: Serves as a certified reference material (CRM) for identifying and controlling process-related impurities in active pharmaceutical ingredient (API) manufacturing.
• Analytical Method Development: Essential for developing and validating robust chromatographic methods for drug substance and drug product analysis.

Basic Information

Product Name	n-Hydroxy Ropinirole Hcl
CAS No.	1542267-72-0
Molecular Formula	C16H25N3O2 • HCl
Molecular Weight	327.85 g/mol (Free base: 291.39 g/mol)
Synonyms	4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one, N-Oxide Hydrochloride; Ropinirole N-Oxide Hydrochloride; 7-Hydroxy Ropinirole Hydrochloride (positional isomer); SKF-101468 Hydroxy Metabolite; ADL-5893 Related Compound; N-Hydroxy Ropinirole Hydrochloride Salt
EINECS	Contact for details

Quality Control

Every batch of n-Hydroxy Ropinirole Hcl is manufactured under strict quality management systems. Our products undergo rigorous identity, purity, and impurity profile testing using advanced analytical techniques (HPLC, GC-MS, NMR) to ensure compliance with research and reference standard grade specifications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.