Description

tert-Butyl 2,6-Diazaspiro[3.4]Octane-6-Carboxylate Hemioxalate is a high-value, protected spirocyclic diamine derivative used as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the construction of complex molecular architectures with potential therapeutic activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel active pharmaceutical ingredients (APIs), particularly in areas requiring constrained, three-dimensional scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Scaffold: Provides a rigid, spirocyclic framework for structure-activity relationship (SAR) studies and library synthesis.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component due to its diamine functionality and favorable physicochemical properties.
• Peptidomimetic Synthesis: Used to create conformationally restricted peptide analogs to enhance metabolic stability and binding affinity.
• Chemical Biology Probe Development: Incorporated into tool compounds for target identification and validation in biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 2,6-Diazaspiro[3.4]Octane-6-Carboxylate Hemioxalate
CAS No.	1523618-25-8
Molecular Formula	C12H20N2O2 • 0.5C2H2O4
Molecular Weight	Contact for details
Synonyms	6-Boc-2,6-diazaspiro[3.4]octane hemioxalate; tert-Butyl 2,6-diazaspiro[3.4]octane-6-carboxylate hemioxalate; 2,6-Diazaspiro[3.4]octane-6-carboxylic acid, 1,1-dimethylethyl ester, hemioxalate; Boc-2,6-diazaspiro[3.4]octane hemioxalate; 6-(tert-Butoxycarbonyl)-2,6-diazaspiro[3.4]octane hemioxalate; 1523618-25-8; Spirocyclic diamine Boc-protected hemioxalate salt.
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,6-Diazaspiro[3.4]Octane-6-Carboxylate Hemioxalate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development from research to commercial scale with appropriate documentation standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.