Description

4-Piperidinone, 3,3-Difluoro-, Hydrochloride (1:1) is a high-purity, fluorinated piperidinone derivative that serves as a critical advanced pharmaceutical intermediate. Its value lies in the unique reactivity imparted by the difluoro substitution, enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel active ingredients in drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Chemical Biology Probe Development: Serves as a precursor for creating fluorinated probes and ligands used in biochemical assays and target identification.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced materials with unique properties.
• Medicinal Chemistry Scaffold: Provides a versatile core structure for generating diverse compound libraries in high-throughput screening campaigns.

Basic Information

Product Name	4-Piperidinone, 3,3-Difluoro-, Hydrochloride (1:1)
CAS No.	1523618-12-3
Molecular Formula	C5H8F2NO • HCl
Molecular Weight	179.58 g/mol (Free base: 143.12 g/mol)
Synonyms	3,3-Difluoropiperidin-4-one hydrochloride; 3,3-Difluoro-4-piperidone hydrochloride; 4-Piperidinone, 3,3-difluoro-, hydrochloride; 3,3-Difluoro-4-oxopiperidine hydrochloride; 1-(3,3-Difluoro-4-oxopiperidin-1-yl)ethanone hydrochloride (common misassignment); Difluorinated Piperidinone HCl Salt
EINECS	Contact for details

Quality Control

Our 4-Piperidinone, 3,3-Difluoro-, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.