Description

trans-(3-Fluorocyclobutyl)Methamine Hcl is a high-purity fluorinated cyclobutylamine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in the unique three-dimensional structure and fluorine atom, which are instrumental for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) active drugs, protease inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorocyclobutyl moiety can enhance bioavailability and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis or as a structural component in organocatalysts.
• Material Science: Potential building block for advanced polymers and liquid crystals, leveraging the rigidity of the cyclobutane ring.
• Chemical Biology & Proteomics: Can be incorporated into molecular probes and activity-based protein profiling (ABPP) agents to study enzyme function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for custom synthesis projects requiring specific fluorinated scaffolds.

Basic Information

Product Name	trans-(3-Fluorocyclobutyl)Methamine Hcl
CAS No.	1523618-03-2
Molecular Formula	C5H11ClFN
Molecular Weight	139.60 g/mol (Free base: 103.15 g/mol)
Synonyms	trans-1-(Aminomethyl)-3-fluorocyclobutane hydrochloride; (1R,3S)-3-Fluorocyclobutylmethanamine hydrochloride (if enantiomerically pure); (1S,3R)-3-Fluorocyclobutylmethanamine hydrochloride; 3-Fluorocyclobutanemethanamine HCl, trans-; trans-3-Fluorocyclobutanemethylamine hydrochloride; FCBMA-HCl; 1-(Aminomethyl)-3-fluorocyclobutane HCl (trans-)
EINECS	Contact for details

Quality Control

Every batch of trans-(3-Fluorocyclobutyl)Methamine Hcl is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and NMR for structural verification, to ensure compliance with exacting customer and research standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans- isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.