Description

2,2-Difluoro-7-Azaspiro[3.5]Nonane Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic disorders. It is primarily sought by research institutions, custom synthesis firms, and pharmaceutical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those requiring a rigid, fluorinated spirocyclic scaffold.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to modulate the pharmacokinetic and pharmacodynamic properties of new chemical entities.
• CNS Drug Development: Employed in the research and development of therapeutics for neurological conditions, leveraging the potential of the 7-azaspiro[3.5]nonane core.
• Proteolysis Targeting Chimera (PROTAC) Linkers: Serves as a component in the design of bifunctional molecules for targeted protein degradation technologies.
• Agrochemical Research: Potential use as an intermediate in the development of new generation pesticides and herbicides with enhanced activity.
• Material Science: Exploration as a monomer or additive for creating specialty polymers with specific fluorinated characteristics.

Basic Information

Product Name	2,2-Difluoro-7-Azaspiro[3.5]Nonane Hydrochloride
CAS No.	1523618-02-1
Molecular Formula	C8H14ClF2N
Molecular Weight	197.65 g/mol
Synonyms	7-Azaspiro[3.5]nonane, 2,2-difluoro-, hydrochloride; 2,2-Difluoro-7-azaspiro[3.5]nonane HCl; 2,2-Difluoro-7-azaspiro[3.5]nonane hydrochloride; 2,2-Difluoro-7-azaspiro[3.5]nonane monohydrochloride; 1523618-02-1; 2,2-Difluoro-7-azaspiro[3.5]nonane, hydrochloride; 2,2-Difluoro-7-azaspiro[3.5]nonane, HCl salt
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-7-Azaspiro[3.5]Nonane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in GMP and non-GMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.