Description

trans-(3-Aminocyclobutyl)Acetic Acid HCl is a high-purity, pharmaceutically relevant building block characterized by its unique cyclobutane scaffold and functionalized acetic acid moiety. This compound is of significant value in medicinal chemistry for constructing novel molecular architectures with potential biological activity. It is primarily sought after by research and development teams in the pharmaceutical and biotechnology sectors for use in drug discovery programs, particularly in the synthesis of targeted small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug candidates.
• Peptidomimetics & Conformationally Restricted Analogs: Used to introduce rigid, strained cyclobutane rings into peptide backbones or small molecules to enhance metabolic stability, potency, and selectivity.
• Ligand Synthesis for Drug Discovery: Serves as a versatile scaffold for constructing focused libraries targeting various enzymes and receptors, such as kinases and GPCRs.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and molecular probes for studying biological pathways and target engagement.
• Agrochemical Research: Potential intermediate in the development of novel herbicides or pesticides with unique modes of action.
• Material Science: Can be utilized as a monomer or cross-linker precursor for specialty polymers with tailored thermal and mechanical properties.

Basic Information

Product Name	trans-(3-Aminocyclobutyl)Acetic Acid HCl
CAS No.	1523606-40-7
Molecular Formula	C6H12ClNO2
Molecular Weight	165.62 g/mol
Synonyms	(1r,3r)-3-Aminocyclobutaneacetic Acid Hydrochloride; trans-3-Aminocyclobutane-1-acetic Acid Hydrochloride; (1R,3R)-3-Aminocyclobutylacetic Acid HCl; 3-Aminocyclobutaneacetic Acid HCl (trans); Acetic Acid, 2-[(1r,3r)-3-aminocyclobutyl]-, Hydrochloride; (3-Aminocyclobutyl)Acetic Acid Hydrochloride, trans-; 1523606-40-7; UNII-Contact for details
EINECS	Contact for details

Quality Control

Every batch of trans-(3-Aminocyclobutyl)Acetic Acid HCl is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.