Description

(3-Fluorocyclobutyl)Methamine Hcl is a high-purity fluorinated cyclobutylamine building block, essential for advanced pharmaceutical and agrochemical research. Its unique structure, featuring a fluorinated cyclobutane ring, makes it a critical intermediate for introducing conformational rigidity and modulating physicochemical properties in active molecules. This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and crop protection industries for the synthesis of novel therapeutic and agrochemical candidates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drug candidates, particularly in oncology, CNS, and metabolic disease research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorocyclobutyl moiety enhances biological activity and environmental stability.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating molecular probes to study enzyme function and protein-ligand interactions.
• Material Science Research: Potential monomer or additive for specialty polymers where fluorine incorporation can alter surface properties and stability.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.

Basic Information

Product Name	(3-Fluorocyclobutyl)Methamine Hcl
CAS No.	1523606-29-2
Molecular Formula	C5H11ClFN
Molecular Weight	139.60 g/mol
Synonyms	(3-Fluorocyclobutyl)methanamine hydrochloride; 1-(3-Fluorocyclobutyl)methanamine HCl; (3-Fluorocyclobutyl)methylamine hydrochloride; 3-Fluorocyclobutanemethanamine hydrochloride; (3-Fluorocyclobutyl)methanamine HCl salt; 1-(Aminomethyl)-3-fluorocyclobutane hydrochloride; 3-Fluoro-cyclobutanemethylamine hydrochloride; 3-Fluorocyclobutylmethylamine HCl
EINECS	Contact for details

Quality Control

Every batch of (3-Fluorocyclobutyl)Methamine Hcl is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.