Description

(2R)-1,4-Dioxane-2-Methanamine Hydrochloride is a chiral amine derivative with a dioxane ring, supplied as a stable hydrochloride salt. This compound is a valuable chiral building block and intermediate in the synthesis of complex organic molecules, particularly in the pharmaceutical sector. It is essential for researchers and manufacturers in medicinal chemistry, process development, and fine chemical synthesis who require high-purity, enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of active pharmaceutical ingredients (APIs), especially those targeting neurological or metabolic pathways.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries in drug discovery programs for hit-to-lead optimization.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of enantiopure drugs.
• Fine Chemical Production: Acts as a specialized intermediate in the synthesis of agrochemicals, flavors, fragrances, and advanced materials.
• Academic Research: Utilized in universities and R&D institutes for studying reaction mechanisms, developing new synthetic methodologies, and creating novel chiral catalysts.

Basic Information

Item	Detail
Product Name	(2R)-1,4-Dioxane-2-Methanamine Hydrochloride
CAS No.	1523541-84-5
Molecular Formula	C6H14ClNO2
Molecular Weight	167.63 g/mol
Synonyms	(R)-1,4-Dioxan-2-ylmethanamine hydrochloride; (2R)-1,4-Dioxan-2-ylmethanamine hydrochloride; (R)-2-(Aminomethyl)-1,4-dioxane hydrochloride; (R)-1,4-Dioxane-2-methanamine HCl; (R)-1,4-Dioxane-2-methylamine hydrochloride; (R)-2-Aminomethyl-1,4-dioxane hydrochloride; (R)-C-1,4-Dioxan-2-yl-methylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (2R)-1,4-Dioxane-2-Methanamine Hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.