Description

Exo-4-Hydroxy-6-Aza-Bicyclo[3.2.0]Heptane-6-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique bicyclic lactam structure. This compound is of significant commercial value as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly β-lactamase inhibitors and other complex therapeutic agents. It is primarily sought after by R&D laboratories, process chemists, and manufacturers in the global pharmaceutical and fine chemical industries for the development of next-generation antibiotics and specialized drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel β-lactam antibiotics and β-lactamase inhibitors.
• API Development: Serves as a crucial precursor in the research and process development of complex Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates targeting bacterial infections.
• Process Chemistry: Employed in route scouting and scale-up synthesis for cost-effective and robust manufacturing processes.
• Fine Chemical Synthesis: Utilized in the preparation of other specialized, high-value nitrogen-containing heterocyclic compounds.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	Exo-4-Hydroxy-6-Aza-Bicyclo[3.2.0]Heptane-6-Carboxylic Acid tert-Butyl Ester
CAS No.	1523530-69-9
Molecular Formula	C11H17NO3
Molecular Weight	211.26 g/mol
Synonyms	(3aS,6R,7aS)-6-Hydroxyhexahydro-1H-3a,6-epoxyisoindole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3aS,6R,7aS)-6-hydroxyhexahydro-1H-3a,6-epoxyisoindole-1-carboxylate; Exo-4-Hydroxy-6-aza-bicyclo[3.2.0]heptane-6-carboxylic acid tert-butyl ester; 6-Azabicyclo[3.2.0]heptane-6-carboxylic acid, 4-hydroxy-, 1,1-dimethylethyl ester, (1R,5S,6S)-rel-; Bicyclic β-lactam intermediate; tert-Butyl 4-hydroxy-6-azabicyclo[3.2.0]heptane-6-carboxylate (exo)
EINECS	Contact for details

Quality Control

Our production of Exo-4-Hydroxy-6-Aza-Bicyclo[3.2.0]Heptane-6-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure compliance with exacting customer specifications and industry standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.