Description

Methyl (3R)-Pyrrolidine-3-Carboxylate Trifluoroacetate is a high-purity chiral intermediate and building block of significant importance in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly those with defined stereochemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of drug candidates targeting neurological disorders, antiviral agents, and other therapeutic areas.
• Agrochemical Research: Used in the development of novel, stereoselective pesticides and herbicides where specific chirality impacts biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Proline Analogs: Integral for constructing constrained peptide analogs and non-natural amino acids for biochemical studies.
• Academic and R&D Laboratories: Employed in methodological development and exploratory chemistry for new synthetic routes.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring high enantiopurity and reliable supply.

Basic Information

Product Name	Methyl (3R)-Pyrrolidine-3-Carboxylate Trifluoroacetate
CAS No.	1523530-44-0
Molecular Formula	C8H12F3NO4
Molecular Weight	243.18 g/mol
Synonyms	(R)-Methyl 3-pyrrolidinecarboxylate trifluoroacetate; Methyl (R)-3-pyrrolidinecarboxylate trifluoroacetate; (3R)-1,2,5,6-Tetrahydropyridine-3-carboxylic acid methyl ester trifluoroacetate; (R)-1,2,5,6-Tetrahydropyridine-3-carboxylic acid methyl ester TFA salt; (R)-Methyl tetrahydropyridine-3-carboxylate TFA salt; (R)-Methyl 1,2,5,6-tetrahydropyridine-3-carboxylate trifluoroacetate; (R)-Methyl 3-piperidinecarboxylate trifluoroacetate (common misnomer); (R)-Methyl 3-carbomethoxypyrrolidine TFA salt
EINECS	Contact for details

Quality Control

Our Methyl (3R)-Pyrrolidine-3-Carboxylate Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Enantiomeric Excess)	≥98.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.