Description

6-(Difluoromethoxy)Picolinic Acid is a high-value, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a difluoromethoxy substituent on the picolinic acid scaffold, makes it indispensable for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Ligand Synthesis: Acts as a precursor for chelating ligands in catalysis and material science applications.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Fluorinated Building Block: Serves as a versatile fluorinated intermediate for introducing the difluoromethoxy moiety into more complex chemical architectures.

Basic Information

Product Name	6-(Difluoromethoxy)Picolinic Acid
CAS No.	1522367-81-2
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	6-(Difluoromethoxy)-2-pyridinecarboxylic Acid; 2-Pyridinecarboxylic acid, 6-(difluoromethoxy)-; 6-(Difluoromethoxy)pyridine-2-carboxylic Acid; 6-Difluoromethoxypicolinic Acid; Picolinic acid, 6-(difluoromethoxy)-; 1522367-81-2
EINECS	Contact for details

Quality Control

Every batch of 6-(Difluoromethoxy)Picolinic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are supported by a detailed Certificate of Analysis (COA) that includes results from HPLC, NMR, and mass spectrometry. We adhere to cGMP principles where applicable to meet the stringent requirements of our global clientele in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.