Description

4-{[(tert-Butoxy)Carbonyl]Amino}Oxolane-3-Carboxylic Acid CAS NO 1521431-12-8 is a high-purity, protected amino acid derivative featuring a tetrahydrofuran (oxolane) backbone. This compound is a critical pharmaceutical intermediate and building block for the synthesis of complex molecules, particularly in peptide and peptidomimetic chemistry. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Peptide Synthesis: Used for introducing constrained, non-natural amino acid residues into peptide chains to enhance stability and biological activity.
• Protease Inhibitor Development: Serves as a core scaffold in the design of inhibitors targeting specific proteolytic enzymes.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the creation of focused libraries for screening.
• Bioconjugation: The carboxylic acid and protected amine functionalities allow for selective conjugation to other molecules or surfaces.
• Academic & Contract Research: A valuable reagent for research institutions and CROs (Contract Research Organizations) exploring new therapeutic modalities.

Basic Information

Product Name	4-{[(tert-Butoxy)Carbonyl]Amino}Oxolane-3-Carboxylic Acid
CAS No.	1521431-12-8
Molecular Formula	C10H17NO5
Molecular Weight	231.25 g/mol
Synonyms	4-((tert-Butoxycarbonyl)amino)tetrahydrofuran-3-carboxylic Acid; 4-(Boc-amino)oxolane-3-carboxylic Acid; 4-(Boc-amino)tetrahydrofuran-3-carboxylic Acid; (3S,4S)-4-[(tert-Butoxycarbonyl)amino]tetrahydrofuran-3-carboxylic Acid (for specific stereoisomer); 4-N-Boc-amino-3-carboxytetrahydrofuran; Boc-4-amino-THF-3-carboxylic Acid; 1521431-12-8; 4-(Boc-amino)THF-3-COOH
EINECS	Contact for details

Quality Control

Our 4-{[(tert-Butoxy)Carbonyl]Amino}Oxolane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.