Description

1-(2-Chlorophenyl)Cyclobutan-1-Ol is a versatile chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its unique structure, featuring a cyclobutanol ring adjacent to a chlorinated aromatic system, makes it a valuable precursor for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and insecticides, leveraging the chlorophenyl moiety for bioactivity.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands used in asymmetric catalysis, such as in transition metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with tailored thermal or optical properties.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, including ring-expansion and strain-release functionalization reactions.

Basic Information

Product Name	1-(2-Chlorophenyl)Cyclobutan-1-Ol
CAS No.	1511366-61-2
Molecular Formula	C10H11ClO
Molecular Weight	182.65 g/mol
Synonyms	1-(2-Chlorophenyl)cyclobutan-1-ol; 2-Chloro-α-(1-hydroxycyclobutyl)benzene; 1-(2-Chlorophenyl)-1-cyclobutanol; (2-Chlorophenyl)cyclobutylmethanol; α-Hydroxy-2-chlorophenylcyclobutane; Cyclobutanol, 1-(2-chlorophenyl)-; 1-(o-Chlorophenyl)cyclobutan-1-ol
EINECS	Contact for details

Quality Control

Our 1-(2-Chlorophenyl)Cyclobutan-1-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and process development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage under an inert atmosphere (e.g., nitrogen or argon), please contact our technical team.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomerically enriched)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.