Description

Pyridine, 2-[(4S,5R)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-6-Phenyl- is a high-purity, chiral oxazoline-substituted pyridine derivative, serving as a sophisticated building block in advanced organic synthesis. Its value lies in its well-defined stereochemistry and rigid molecular architecture, which are critical for inducing enantioselectivity in catalytic systems and constructing complex molecular frameworks. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise chiral ligands or intermediates for asymmetric synthesis and material science applications.

Application

• Asymmetric Catalysis: Employed as a chiral ligand or precursor for ligands in transition metal-catalyzed reactions, including asymmetric hydrogenation, cyclopropanation, and C–H activation.
• Pharmaceutical Intermediates: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators where specific stereochemistry impacts biological activity.
• Material Science: Serves as a functional monomer or cross-linker in the synthesis of chiral polymers, liquid crystals, and metal-organic frameworks (MOFs) with advanced optical or catalytic properties.
• Academic & Process R&D: A valuable tool for methodology development in academic laboratories and for scaling up enantioselective processes in industrial R&D settings.

Basic Information

Item	Details
Product Name	Pyridine, 2-[(4S,5R)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-6-Phenyl-
CAS No.	1509929-23-0
Molecular Formula	C26H20N2O
Molecular Weight	376.45 g/mol
Synonyms	(4S,5R)-4,5-Dihydro-2-(6-phenylpyridin-2-yl)-4,5-diphenyloxazole; (S,R)-2-(6-Phenylpyridin-2-yl)-4,5-dihydro-4,5-diphenyloxazole; 2-[(4S,5R)-4,5-Dihydro-4,5-diphenyl-2-oxazolyl]-6-phenylpyridine; Chiral Pyridine-Oxazoline Ligand; (S,R)-PyOx Ligand; (4S,5R)-H4Ph-PyOx; (S,R)-Inda-PyOx analog
EINECS	Contact for details

Quality Control

Every batch of Pyridine, 2-[(4S,5R)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-6-Phenyl- is produced and tested under strict quality management systems to ensure exceptional chiral purity and chemical integrity. Our standard quality commitment includes comprehensive analysis via HPLC, NMR, and chiral chromatography to confirm enantiomeric excess (ee) and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters. Specifications can be developed to meet cGMP, ICH Q7, or other stringent regulatory guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). For long-term storage under an inert atmosphere (argon or nitrogen), please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.