Description

8-Bromo-3,4-Dihydroquinazolin-2(1H)-One is a high-value brominated quinazolinone derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a versatile halogenated scaffold for constructing complex heterocyclic molecules, enabling efficient structure-activity relationship (SAR) studies and lead optimization. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly those developing novel kinase inhibitors, receptor modulators, and other bioactive small molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel quinazolinone-based drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Used in lead compound optimization and SAR studies, leveraging the bromine atom for further functionalization via cross-coupling reactions.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new herbicides, fungicides, or plant growth regulators.
• Chemical Biology Probes: Utilized to create tool compounds for probing biological pathways and enzyme functions.
• Material Science Research: Potential monomer or precursor for the development of specialty polymers or organic electronic materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Product Name	8-Bromo-3,4-Dihydroquinazolin-2(1H)-One
CAS No.	1508072-34-1
Molecular Formula	C8H7BrN2O
Molecular Weight	227.06 g/mol
Synonyms	8-Bromo-1,2,3,4-tetrahydroquinazolin-2-one; 8-Bromo-3,4-dihydro-2(1H)-quinazolinone; 8-Bromo-1,2,3,4-tetrahydro-2-quinazolinone; 8-Bromotetrahydroquinazolin-2(1H)-one; 2H-Quinazolin-2-one, 8-bromo-3,4-dihydro-1-; 8-Bromo-1,2,3,4-tetrahydroquinazolin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 8-Bromo-3,4-Dihydroquinazolin-2(1H)-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.