Description

Methanesulfonato [2-(Di-1-Adamantylphosphino)-2',4',6'-Triisopropyl-3,6-Dimethoxybiphenyl][2-(2'-Amino-1,1'-Biphenyl)]Palladium(II) is a highly specialized, Buchwald-type palladium precatalyst designed for demanding cross-coupling reactions. Its value lies in its exceptional air and moisture stability, which simplifies handling and storage compared to more sensitive catalysts, while delivering high activity and selectivity. This compound is essential for researchers and process chemists in pharmaceutical development, agrochemical synthesis, and advanced materials science, where it enables efficient C–N and C–C bond formation. The CAS number for this product is 1507404-60-5.

Application

This advanced palladium precatalyst is engineered for high-performance applications in synthetic organic chemistry, particularly where robust and reliable catalytic systems are required.

• Pharmaceutical Intermediate Synthesis: Key for constructing complex drug molecules via Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Active Ingredient Production: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring selective aryl-amine coupling.
• Materials Science & OLED Development: Facilitates the synthesis of conjugated polymers and organic electronic materials through efficient C–C bond formation.
• Academic & Process R&D: A preferred catalyst for method development and scaling up challenging coupling reactions due to its stability and performance.
• Fine Chemical Manufacturing: Enables the production of specialty chemicals, flavors, and fragrances that require palladium-catalyzed steps.

Basic Information

Product Name	Methanesulfonato [2-(Di-1-Adamantylphosphino)-2',4',6'-Triisopropyl-3,6-Dimethoxybiphenyl][2-(2'-Amino-1,1'-Biphenyl)]Palladium(II)
CAS No.	1507404-60-5
Molecular Formula	C55H74NO5PPdS
Molecular Weight	1011.60 g/mol
Synonyms	Buchwald Palladium Precatalyst G4; Methanesulfonato AdBippyPhos Pd(II) Amine Complex; Pd-PEPPSI-IPent®-An (Analog); Palladium(II) Methanesulfonate AdBippyPhos Amine Complex; [2-(2-Aminobiphenyl)]Pd(ms)(AdBippyPhos); Pd(dba)2/AdBippyPhos Alternative; Air-Stable Pd Precatalyst for C-N Coupling; (2-Di-1-adamantylphosphino-2',4',6'-triisopropyl-3,6-dimethoxybiphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) methanesulfonate
EINECS	Contact for details

Quality Control

Every batch of our palladium precatalyst is manufactured and tested to meet the stringent requirements of research and industrial-scale applications. We employ advanced analytical techniques including NMR, HPLC, and elemental analysis to verify identity, purity, and catalytic activity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results. Our quality system supports compliance with cGMP and ISO 9001 standards for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (argon or nitrogen) in a cool, dry place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air and moisture should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	Yellow to orange-brown crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Palladium (Pd) Content	9.8 - 10.8 %
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.