Description

2-Bromo-9,9-Difluoro-7-Iodo-9H-Fluorene is a highly functionalized, multi-halogenated fluorene derivative that serves as a critical advanced intermediate in synthetic organic chemistry. Its unique structure, featuring bromine, iodine, and fluorine substituents, makes it a versatile and valuable building block for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, particularly for developing novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and metabolic stability.
• Organic Light-Emitting Diodes (OLEDs): Serves as a precursor for electron-transport materials (ETMs) or host materials in OLED devices due to the fluorene core and halogen substituents influencing charge transport.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis, particularly in cross-coupling reactions where the halogens offer orthogonal reactivity for sequential functionalization.
• Polymer & Material Science: A monomer or functionalization agent for creating high-performance polymers with specific optical, electronic, or surface properties.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis, including studies on halogen dance reactions and sequential cross-coupling methodologies.

Basic Information

Product Name	2-Bromo-9,9-Difluoro-7-Iodo-9H-Fluorene
CAS No.	1499193-60-0
Molecular Formula	C13H5BrF2I
Molecular Weight	420.99 g/mol
Synonyms	9H-Fluorene, 2-bromo-9,9-difluoro-7-iodo-; 2-Bromo-9,9-difluoro-7-iodofluorene; 7-Iodo-2-bromo-9,9-difluorofluorene; Difluoroiodobromofluorene; 1499193-60-0; AI3-76066; SCHEMBL21883027; DTXSID70731892
EINECS	Contact for details

Quality Control

Our 2-Bromo-9,9-Difluoro-7-Iodo-9H-Fluorene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.