Description

7-Oxa-5-Azaspiro[3.4]Octan-6-One is a high-value, spirocyclic heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its unique fused ring structure makes it a versatile intermediate for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and material science industries seeking to innovate with constrained, three-dimensional scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas requiring rigid, spirocyclic motifs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the spirocyclic structure can impart unique biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a sophisticated backbone for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Investigated as a monomer or additive for creating polymers with specific thermal or mechanical properties due to its constrained geometry.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed as a linker or core structure in the design of bifunctional molecules for targeted protein degradation.
• Academic & Contract Research: A valuable reagent for methodological development and exploration of new synthetic routes in university and CRO laboratories.

Basic Information

Product Name	7-Oxa-5-Azaspiro[3.4]Octan-6-One
CAS No.	1491642-09-1
Molecular Formula	C6H9NO2
Molecular Weight	127.14 g/mol
Synonyms	7-Oxa-5-azaspiro[3.4]octan-6-one; 5-Azaspiro[3.4]octan-7-one, 6-oxa-; 6-Oxa-5-azaspiro[3.4]octan-7-one; Spiro[oxetane-3,3'-pyrrolidin]-2'-one; Oxetane-spiro-pyrrolidinone; 1-Oxa-4-azaspiro[4.3]octan-5-one (tautomeric form); Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our 7-Oxa-5-Azaspiro[3.4]Octan-6-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support custom synthesis and can tailor specifications to meet specific project needs, including compliance with ISO and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.