Description

6'-Bromo-3',4'-Dihydro-1'H-Spiro[Azetidine-2,2'-Naphthalene] is a high-value, spirocyclic organic building block featuring a fused azetidine-naphthalene core structure. This compound is critical for medicinal chemistry research and pharmaceutical development, serving as a versatile intermediate for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce novel spirocyclic motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets, leveraging its spirocyclic scaffold.
• Medicinal Chemistry Research: Used as a constrained building block to explore structure-activity relationships (SAR) and improve the metabolic stability and selectivity of lead compounds.
• Agrochemical Development: Intermediate in the research and synthesis of new-generation pesticides and herbicides with unique modes of action.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and enzyme functions.
• Material Science Research: Potential monomer or precursor for specialty polymers and organic electronic materials due to its rigid, three-dimensional structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this specialized brominated spiro compound.

Basic Information

Product Name	6'-Bromo-3',4'-Dihydro-1'H-Spiro[Azetidine-2,2'-Naphthalene]
CAS No.	1478735-16-8
Molecular Formula	C14H16BrN
Molecular Weight	278.19 g/mol
Synonyms	6'-Bromo-3',4'-dihydro-1'H-spiro[azetidine-2,2'-naphthalene]; 1'H-Spiro[azetidine-2,2'-naphthalene], 6'-bromo-3',4'-dihydro-; 6'-Bromospiro[azetidine-2,2'-3',4'-dihydronaphthalene]; Spiro[azetidine-2,2'-naphthalene], 6'-bromo-3',4'-dihydro-; 1478735-16-8; Bromo-spiro azetidine naphthalene; 6-Bromo-3,4-dihydrospiro[naphthalene-2,2'-azetidine]; 6'-Bromo-1'H-spiro[azetidine-2,2'-naphthalen]-3',4'-diene (incorrect but common search variant)
EINECS	Contact for details

Quality Control

Our 6'-Bromo-3',4'-Dihydro-1'H-Spiro[Azetidine-2,2'-Naphthalene] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical characteristics. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.