Description

(1R)-1-Amino-4-(Trifluoromethyl)Indane Hydrochloride CAS NO 1466429-18-4 is a high-purity chiral amine building block and pharmaceutical intermediate. This compound is valued for its unique indane scaffold and trifluoromethyl group, which are critical for modulating the biological activity, metabolic stability, and lipophilicity of advanced drug candidates. It is primarily required by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics, particularly in areas such as central nervous system (CNS) disorders and oncology.

Application

• Key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs).
• Critical intermediate in medicinal chemistry research for structure-activity relationship (SAR) studies.
• Precursor for the development of potential CNS-targeting drugs, including receptor modulators.
• Used in the preparation of compounds for high-throughput screening and biological evaluation.
• Essential for process chemistry development and scale-up of candidate drug molecules.
• Building block for creating molecular libraries in combinatorial chemistry.

Basic Information

Product Name	(1R)-1-Amino-4-(Trifluoromethyl)Indane Hydrochloride
CAS No.	1466429-18-4
Molecular Formula	C10H10F3N • HCl
Molecular Weight	237.65 g/mol
Synonyms	(1R)-1-Amino-4-(trifluoromethyl)-2,3-dihydro-1H-indene hydrochloride; (R)-1-Amino-4-(trifluoromethyl)indane HCl; 1H-Indene-1-amine, 4-(trifluoromethyl)-, (1R)-, hydrochloride; (1R)-4-(Trifluoromethyl)-1-indanamine hydrochloride; (R)-4-(Trifluoromethyl)indan-1-amine hydrochloride; (R)-1-Amino-4-trifluoromethylindane hydrochloride; (R)-ATI hydrochloride
EINECS	Contact for details

Quality Control

Our (1R)-1-Amino-4-(Trifluoromethyl)Indane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.