Description

1-(2,2,2-Trifluoroethyl)Cyclopropan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclopropane and trifluoroethyl amine hydrochloride structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and metabolic disorders. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate fluorinated motifs for enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring fluorinated cyclopropane scaffolds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties of lead compounds.
• Agrochemical Synthesis: Serves as a precursor in developing advanced pesticides and herbicides with improved efficacy and environmental profiles.
• Fluorinated Compound Library: Essential for constructing diverse screening libraries in drug discovery programs focused on fluorinated molecules.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of complex target molecules.
• Fine Chemical Synthesis: Used in the preparation of specialized fluorinated compounds for advanced material science and electronics applications.

Basic Information

Product Name	1-(2,2,2-Trifluoroethyl)Cyclopropan-1-Amine Hydrochloride
CAS No.	1461714-70-4
Molecular Formula	C5H9ClF3N
Molecular Weight	175.58 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)cyclopropanamine hydrochloride; 1-(Trifluoroethyl)cyclopropylamine HCl; Cyclopropanamine, 1-(2,2,2-trifluoroethyl)-, hydrochloride; 1-Cyclopropyl-2,2,2-trifluoroethylamine hydrochloride; (1-(2,2,2-Trifluoroethyl)cyclopropyl)amine hydrochloride; 1-Aminocyclopropane-1-(2,2,2-trifluoroethyl) hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2,2,2-Trifluoroethyl)Cyclopropan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliable consistency and traceability for your research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.