Description

2H-Pyrrolo[2,3-B]Pyridin-2-One, 3-[[5-Chloro-3-[[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Methyl]-2-Pyridinyl]Methylene]-1-(1,1-Dimethylethyl)-1,3-Dihydro-, (3Z)- is a sophisticated heterocyclic organic compound featuring a pyrrolopyridine core with a protected hydroxymethyl pyridine substituent. This molecule serves as a critical advanced intermediate in modern pharmaceutical research and development, enabling the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and CDMOs engaged in the discovery and scale-up of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates targeting various disease pathways.
• Kinase Inhibitor Development: Core scaffold in the research and production of small molecule kinase inhibitors for oncology and inflammatory diseases.
• Preclinical & Clinical Trial Material: Sourced for the preparation of high-purity compounds required for pharmacological studies and early-stage clinical supplies.
• Process Chemistry & Route Scouting: Used by medicinal and process chemists to develop efficient and scalable synthetic routes for target molecules.
• Chemical Biology Probes: Utilized in the creation of specialized probes for studying enzyme function and cellular signaling mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the custom synthesis of client-specific derivatives and analogs under cGMP or research-grade conditions.

Basic Information

Product Name	2H-Pyrrolo[2,3-B]Pyridin-2-One, 3-[[5-Chloro-3-[[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Methyl]-2-Pyridinyl]Methylene]-1-(1,1-Dimethylethyl)-1,3-Dihydro-, (3Z)-
CAS No.	1456804-07-1
Molecular Formula	C23H26ClN3O3
Molecular Weight	427.92 g/mol
Synonyms	(3Z)-3-[[5-Chloro-3-[[(Tetrahydro-2H-pyran-2-yl)oxy]methyl]-2-pyridinyl]methylene]-1-(1,1-dimethylethyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 1-tert-Butyl-3-[(Z)-(5-chloro-3-((tetrahydro-2H-pyran-2-yloxy)methyl)pyridin-2-yl)methylene]-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; THP-protected Pyrrolopyridine Intermediate; CAS 1456804-07-1
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects with material suitable for research use or produced under cGMP guidelines for advanced clinical stages, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.