Description

Ethyl 8-Benzyl-3-Oxo-1-Oxa-8-Azaspiro[4.5]Decane-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in modern drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of new chemical entities (NCEs) and proprietary drug candidates.
• Drug Discovery & Medicinal Chemistry: Serves as a versatile scaffold for constructing complex molecular architectures with potential biological activity.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale manufacturing of target APIs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service providers supporting pharmaceutical clients with custom synthesis projects.
• Academic & Institutional Research: Employed in chemical biology studies and the development of new synthetic methodologies.

Basic Information

Product Name	Ethyl 8-Benzyl-3-Oxo-1-Oxa-8-Azaspiro[4.5]Decane-4-Carboxylate
CAS No.	1454273-40-5
Molecular Formula	C19H25NO4
Molecular Weight	331.41 g/mol
Synonyms	Ethyl 8-benzyl-3-oxo-1-oxa-8-azaspiro[4.5]decane-4-carboxylate; 1-Oxa-8-azaspiro[4.5]decane-4-carboxylic acid, 8-benzyl-3-oxo-, ethyl ester; 8-Benzyl-3-oxo-1-oxa-8-azaspiro[4.5]decane-4-carboxylic acid ethyl ester; 1454273-40-5; Spirocyclic oxazolidinone derivative; Ethyl 8-benzyl-3-oxo-1-oxa-8-azaspiro[4.5]decane-4-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 8-Benzyl-3-Oxo-1-Oxa-8-Azaspiro[4.5]Decane-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.