Description

tert-Butyl-8-Hydroxy-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate 95% is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic oxazolidinone scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Medicinal Chemistry Building Block: Used in scaffold hopping and structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties of lead compounds.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for target molecules under Good Manufacturing Practice (GMP) guidelines.
• Agrochemical Research: Employed in the synthesis of novel herbicides or fungicides that utilize the spirocyclic structural motif for enhanced biological activity.
• Academic Research: Utilized in universities and research institutes for methodological studies in organic synthesis, particularly in reactions involving heterocycles and chiral auxiliaries.
• Custom Synthesis & Contract Manufacturing: A vital component for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services for client-specific projects.

Basic Information

Product Name	tert-Butyl-8-Hydroxy-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate 95%
CAS No.	1453315-99-5
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	tert-Butyl 8-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; 2-Azaspiro[3.4]octane-2-carboxylic acid, 8-hydroxy-5-oxa-, 1,1-dimethylethyl ester; 8-Hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; Spirocyclic Oxazolidinone Derivative; TBHAOC; (8-Hydroxy-5-oxa-2-azaspiro[3.4]oct-2-yl)carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl-8-Hydroxy-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate 95% is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the specified 95% minimum purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.