Description

2-Boc-8-Oxo-5-Oxa-2-Azaspiro[3.4]Octane 95% is a high-purity, protected spirocyclic building block essential for advanced organic synthesis. This compound is a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of constrained peptidomimetics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in protease inhibitor and constrained peptide research.
• Medicinal Chemistry: Used to introduce the spirocyclic 5-oxa-2-azaspiro[3.4]octane scaffold, which can improve metabolic stability and binding affinity in lead optimization.
• Peptidomimetic Synthesis: Serves as a constrained proline or proline-like surrogate for creating conformationally restricted peptides with enhanced pharmacological properties.
• Chemical Biology Probes: Employed in the construction of specialized molecular tools for studying enzyme function and protein-protein interactions.
• Process Research & Development (R&D): Used in route scouting and scale-up studies for the efficient production of target molecules.
• Academic Research: A valuable reagent for methodology development and exploring new spirocyclic chemical space in synthetic organic chemistry.

Basic Information

Product Name	2-Boc-8-Oxo-5-Oxa-2-Azaspiro[3.4]Octane 95%
CAS No.	1453315-97-3
Molecular Formula	C12H19NO5
Molecular Weight	257.28 g/mol
Synonyms	tert-Butyl 8-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; 2-[(tert-Butoxy)carbonyl]-8-oxo-5-oxa-2-azaspiro[3.4]octane; 2-Boc-8-oxo-5-oxa-2-azaspiro[3.4]octane; 5-Oxa-2-azaspiro[3.4]octane-8-one, 2-[(1,1-dimethylethoxy)carbonyl]-; 2-Boc-8-oxo-5-oxa-2-azaspiro[3.4]octane-95%; Spirocyclic Boc-protected lactam ether.
EINECS	Contact for details

Quality Control

Our 2-Boc-8-Oxo-5-Oxa-2-Azaspiro[3.4]Octane 95% is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.