Description

tert-Butyl 7-Hydroxy-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate is a sophisticated spirocyclic building block of significant interest in advanced organic synthesis. This compound matters because it provides a versatile chiral scaffold containing multiple functional handles, enabling the construction of complex molecular architectures with high precision. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in the development of protease inhibitors and other biologically relevant heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for targeting enzymes and receptors.
• Protease Inhibitor Scaffold: Serves as a core structural element for designing potent inhibitors of proteolytic enzymes.
• Agrochemical Synthesis: Used in the creation of novel, high-performance active ingredients for crop protection products.
• Chemical Biology Probe Development: Employed to build tool compounds for studying biological pathways and target validation.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective chemical transformations.
• Peptidomimetic Research: Integral for designing and synthesizing peptide mimics with enhanced stability and bioavailability.

Basic Information

Product Name	tert-Butyl 7-Hydroxy-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate
CAS No.	1453315-70-2
Molecular Formula	C11H19NO3S
Molecular Weight	245.34 g/mol
Synonyms	7-Hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; tert-Butyl 7-hydroxy-2-azaspiro[3.4]octane-2-carboxylate, 5-thia-; 2-Azaspiro[3.4]octane-2-carboxylic acid, 7-hydroxy-5-thia-, 1,1-dimethylethyl ester; 5-Thia-2-azaspiro[3.4]octane-2-carboxylic acid, 7-hydroxy-, tert-butyl ester; CAS 1453315-70-2; Spirocyclic thia-azetidine carboxylate; Hydroxy-substituted spiro[3.4]octane intermediate.
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Hydroxy-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.