Description

m-Peg4-Hydrazide CAS NO 1449390-68-4 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a hydrazide group at one terminus. This functional group is highly valuable for site-specific conjugation chemistry, enabling the formation of stable hydrazone or acylhydrazone bonds with aldehydes and ketones. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for the development of advanced drug delivery systems, antibody-drug conjugates (ADCs), and PEGylated therapeutics.

Application

• Bioconjugation Linker: Used for the site-specific conjugation of drugs, peptides, or fluorescent dyes to targeting molecules like antibodies or proteins via aldehyde/ketone groups.
• ADC (Antibody-Drug Conjugate) Development: Serves as a critical hydrophilic spacer and linker in ADC payload attachment, improving solubility and pharmacokinetics.
• PEGylation Reagent: Enables the PEGylation of aldehyde-functionalized biomolecules to enhance stability, reduce immunogenicity, and prolong circulation half-life.
• Crosslinking Agent: Employed in hydrogel formation and polymer crosslinking where hydrazide chemistry is required for network formation.
• Surface Modification: Functionalizes aldehyde-presenting surfaces (e.g., oxidized polymers or chips) for biosensor and diagnostic assay development.
• Prodrug Synthesis: Facilitates the creation of acid-sensitive prodrug linkers for controlled drug release in targeted therapeutic applications.

Basic Information

Product Name	m-Peg4-Hydrazide
CAS No.	1449390-68-4
Molecular Formula	C13H28N2O6
Molecular Weight	308.37 g/mol
Synonyms	m-PEG4-Hydrazide; 4,7,10,13-Tetraoxa-16-azaheptadecan-17-hydrazide; m-PEG4-NHNH2; Methoxy-PEG4-hydrazide; 1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid hydrazide; PEG4 methyl ether hydrazide; Amine-PEG4-hydrazide (common naming variant); O-(2-Aminoethyl)-O'-(2-carboxyethyl)undecaethylene glycol hydrazide (related structural description)
EINECS	Contact for details

Quality Control

Our m-Peg4-Hydrazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, store the product under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. For long-term stability, storage at -20°C is recommended. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.