Description

Mpeg4-Hydrazide CAS NO 1449390-65-1 is a specialized functionalized polyethylene glycol derivative, where a terminal hydrazide group is conjugated to a methoxy-PEG4 linker. This compound is engineered to provide a reactive handle for the site-specific conjugation of carbonyl-containing molecules, such as aldehydes and ketones, under mild aqueous conditions. It is a critical reagent for researchers and manufacturers in the fields of bioconjugation, polymer chemistry, and advanced material science, enabling the creation of stable, well-defined conjugates for diagnostic, therapeutic, and research applications.

Application

• Bioconjugation Linker: For the covalent attachment of proteins, antibodies, peptides, or oligonucleotides to surfaces, nanoparticles, or other polymers via reactive aldehyde groups.
• Polymer Functionalization: As a building block for synthesizing smart polymers, hydrogels, and drug delivery systems with tailored reactivity and hydrophilicity.
• Surface Modification: To introduce hydrophilic PEG spacers and reactive hydrazide groups onto solid supports (e.g., chips, beads, sensors) for immobilizing biomolecules.
• Cross-linking Agent: For creating cross-linked networks in biomaterials or diagnostic assays by reacting with dialdehyde or polyaldehyde compounds.
• ADC (Antibody-Drug Conjugate) Payload Attachment: As a component in linker-payload constructs for connecting cytotoxic drugs to antibodies via pH-sensitive or cleavable linkages.
• Diagnostic Reagent Synthesis: In the development of enzyme conjugates, fluorescent probes, and hapten-carrier complexes for immunoassays.

Basic Information

Product Name	Mpeg4-Hydrazide
CAS No.	1449390-65-1
Molecular Formula	C13H28N2O6
Molecular Weight	308.37 g/mol
Synonyms	mPEG4-Hydrazide; Methoxy-PEG4-hydrazide; 2,5,8,11-Tetraoxatridecan-13-oic acid, 13-hydrazinyl-12-oxo-, 1-(1,1-dimethylethyl) 13-methyl ester; α-Methoxy-ω-hydrazino carbonyl tetraethylene glycol; 4,7,10,13-Tetraoxahexadecanoic acid, 16-hydrazinyl-15-oxo-, 1-(1,1-dimethylethyl) 16-methyl ester; mPEG4-NHNH2; PEG-based hydrazide linker
EINECS	Contact for details

Quality Control

Our Mpeg4-Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive conjugation applications. Certificates of Analysis (COA) are provided, detailing specifications for identity, purity, and functional integrity. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent hydrolysis. For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Assay (Hydrazide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.