Description

Ethyl 4-Chloro-7-Nitroquinoline-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a distinct quinoline core structure. This compound matters for its critical role as a versatile building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers focused on developing new therapeutic agents, including kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those targeting specific enzymes and receptors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Kinase Inhibitor Development: Serves as a building block for compounds designed to modulate kinase activity, relevant in oncology and inflammatory disease research.
• Fine Chemical Synthesis: Employed in custom synthesis and process development for producing specialized, high-value compounds.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and biochemical studies.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for scale-up and GMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Ethyl 4-Chloro-7-Nitroquinoline-2-Carboxylate
CAS No.	1447608-14-1
Molecular Formula	C₁₂H₉ClN₂O₄
Molecular Weight	280.66 g/mol
Synonyms	Ethyl 4-chloro-7-nitro-2-quinolinecarboxylate; 2-Quinolinecarboxylic acid, 4-chloro-7-nitro-, ethyl ester; 4-Chloro-7-nitroquinoline-2-carboxylic acid ethyl ester; 7-Nitro-4-chloroquinoline-2-carboxylic acid ethyl ester; Ethyl 7-nitro-4-chloroquinoline-2-carboxylate; 1447608-14-1; UNII-9K7F8Q30M8; 9K7F8Q30M8
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-7-Nitroquinoline-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.