Description

3-(Chloromethyl)-2-(1-Isopropyl-1H-Pyrazol-5-Yl)Pyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1446321-95-4. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), offering a key structural motif for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its versatile pyridine-pyrazole core.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in multi-step synthetic routes for target API molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development and quality control in API production.

Basic Information

Product Name	3-(Chloromethyl)-2-(1-Isopropyl-1H-Pyrazol-5-Yl)Pyridine Hydrochloride
CAS No.	1446321-95-4
Molecular Formula	C13H17Cl2N3
Molecular Weight	286.20 g/mol
Synonyms	2-(1-Isopropyl-1H-pyrazol-5-yl)-3-(chloromethyl)pyridine hydrochloride; 3-(Chloromethyl)-2-(1-isopropyl-1H-pyrazol-5-yl)pyridine HCl; 2-(1-Isopropyl-1H-pyrazol-5-yl)-3-(chloromethyl)pyridinium chloride; 1446321-95-4; Pyridine, 3-(chloromethyl)-2-(1-isopropyl-1H-pyrazol-5-yl)-, hydrochloride; 3-(Chloromethyl)-2-(1-methylethyl-1H-pyrazol-5-yl)pyridine hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized and controlled using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to guarantee identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are available upon request. Our quality system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.