Description

4-Chloro-3-(trifluoromethyl)phenyl trifluoromethanesulphonate (97%) is a high-purity, multi-fluorinated synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a versatile building block for introducing the trifluoromethanesulfonate (triflate) group, a premier leaving group that enables efficient cross-coupling reactions and functional group transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl and chloro substituents contribute to product efficacy and environmental profile.
• Material Science: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and electronic materials requiring specific fluorinated aromatic units.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions such as Suzuki, Stille, and Negishi couplings, facilitating the construction of biaryl and complex aromatic systems.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry groups exploring new synthetic routes and novel chemical entities.
• Fluorinated Compound Library Synthesis: Enables the efficient generation of diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	4-Chloro-3-(trifluoromethyl)phenyl trifluoromethanesulphonate (97%)
CAS No.	1446016-91-6
Molecular Formula	C8H3ClF6O3S
Molecular Weight	328.61 g/mol
Synonyms	4-Chloro-3-(trifluoromethyl)phenyl triflate; 4-Chloro-α,α,α-trifluoro-3-(trifluoromethyl)benzenemethanol sulfonate; 4-Chloro-3-(trifluoromethyl)phenyl trifluoromethanesulfonate; 1-Chloro-2-(trifluoromethyl)-4-[(trifluoromethyl)sulfonyloxy]benzene; 4-Chloro-3-trifluoromethylphenyl triflate; 4-Chloro-3-(trifluoromethyl)phenol triflate; 4-Chloro-α,α,α-trifluoro-3-(trifluoromethyl)benzenemethanesulfonate
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(trifluoromethyl)phenyl trifluoromethanesulphonate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure consistent purity, identity, and lot-to-lot reproducibility suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.