Description

1-Bromo-2-Fluoro-3-(Methylsulphonyl)-5-Nitrobenzene, 3-Bromo-4-Fluoro-5-(Methylsulphonyl)Nitrobenzene CAS NO 1445995-73-2 is a high-purity, multi-functional halogenated nitrobenzene derivative, distinguished by its bromo, fluoro, methylsulfonyl, and nitro substituents. This compound serves as a critical advanced intermediate for synthesizing complex molecules, offering precise reactivity for building intricate chemical architectures. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and specialty materials.

Application

This versatile intermediate is engineered for high-value synthesis applications, including:

• Pharmaceutical Intermediate: A key building block for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogen and sulfone groups for bioactivity.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it a prime candidate for selective substitution reactions in multi-step syntheses.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Item	Detail
Product Name	1-Bromo-2-Fluoro-3-(Methylsulphonyl)-5-Nitrobenzene, 3-Bromo-4-Fluoro-5-(Methylsulphonyl)Nitrobenzene
CAS No.	1445995-73-2
Molecular Formula	C7H5BrFNO4S
Molecular Weight	298.09 g/mol
Synonyms	1-Bromo-2-fluoro-3-(methylsulfonyl)-5-nitrobenzene; 3-Bromo-4-fluoro-5-(methylsulfonyl)nitrobenzene; 2-Fluoro-3-bromo-5-nitrobenzenesulfonylmethane; 5-Nitro-3-bromo-4-fluoro phenyl methyl sulfone; 1-Bromo-2-fluoro-3-(methanesulfonyl)-5-nitrobenzene; 1445995-73-2; Benzene, 1-bromo-2-fluoro-3-(methylsulfonyl)-5-nitro-; MFCD31811862
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluoro-3-(Methylsulphonyl)-5-Nitrobenzene is produced under a strict quality management system. Every batch undergoes rigorous analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.