Description

3-Bromo-6-Nitro-2-(Trifluoromethyl)Phenol, also known as 3-Bromo-6-Nitro-Alpha,Alpha,α-Trifluoro-o-Cresol, is a high-value, multi-functional halogenated aromatic building block. This compound matters for its unique trifluoromethyl and nitro substituents, which are critical for modulating the electronic properties, lipophilicity, and metabolic stability of advanced molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethyl group enhances bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated phenolic structure for potent biological activity.
• Material Science Research: Serves as a specialized monomer or additive in the development of advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Chemical Biology & Proteomics: Employed as a reactive handle or affinity tag in the design of chemical probes for studying enzyme function and protein interactions.
• Dye & Pigment Intermediate: Acts as a building block for synthesizing complex, high-performance dyes and pigments with specific light-fastness and color properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create diverse biaryl structures.

Basic Information

Product Name	3-Bromo-6-Nitro-2-(Trifluoromethyl)Phenol
CAS No.	1445995-70-9
Molecular Formula	C7H3BrF3NO3
Molecular Weight	285.00 g/mol
Synonyms	3-Bromo-6-nitro-α,α,α-trifluoro-o-cresol; 2-Bromo-5-hydroxy-4-nitrobenzotrifluoride; 3-Bromo-6-nitro-2-(trifluoromethyl)phenol; 3-Bromo-6-nitro-α,α,α-trifluoro-2-methylphenol; 2-(Trifluoromethyl)-3-bromo-6-nitrophenol; 3-Bromo-6-nitro-2-trifluoromethylphenol; 3-Bromo-6-nitro-2-(trifluoromethyl)benzenol
EINECS	Contact for details

Quality Control

Our 3-Bromo-6-Nitro-2-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.