Description

1-(3-Aminocyclobutyl)Piperidin-2-One Hydrochloride (Wx604578) is a high-purity, advanced pharmaceutical intermediate with the CAS number 1445951-90-5. This compound is a critical building block in modern medicinal chemistry, valued for its unique cyclobutyl-piperidinone scaffold which is integral to the synthesis of novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new active pharmaceutical ingredients (APIs).
• CNS Drug Development: Serves as a core scaffold for compounds being investigated for neurological and psychiatric disorders.
• Oncology Research: Employed in the synthesis of molecules designed to modulate specific biological pathways involved in cancer.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and protein interactions in biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	1-(3-Aminocyclobutyl)Piperidin-2-One Hydrochloride (Wx604578)
CAS No.	1445951-90-5
Molecular Formula	C9H17ClN2O
Molecular Weight	204.70 g/mol
Synonyms	1-(3-Aminocyclobutyl)-2-piperidinone hydrochloride; 2-Piperidinone, 1-(3-aminocyclobutyl)-, hydrochloride; WX-604578; Wx604578; 1-(3-Aminocyclobutyl)piperidin-2-one HCl; 1445951-90-5; 1-(3-Aminocyclobutyl)-2-piperidinone HCl salt
EINECS	Contact for details

Quality Control

Our 1-(3-Aminocyclobutyl)Piperidin-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.