Description

Methanesulfonato[1,1'-Bis(Diphenylphosphino)Ferrocene)](2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(II), Min. 98% [Dppf Palladacycle Gen. 3] is a highly active and air-stable palladium precatalyst, widely recognized as a third-generation Buchwald-Hartwig amination catalyst. This compound is engineered for superior performance in demanding cross-coupling reactions, offering excellent functional group tolerance and high turnover numbers. It is an essential tool for researchers and process chemists in pharmaceutical development, agrochemical synthesis, and advanced materials science, where efficient C–N and C–C bond formation is critical. The product is supplied with a minimum purity of 98% to ensure consistent and reliable results.

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for Buchwald-Hartwig amination in the production of active pharmaceutical ingredients (APIs), especially for aryl amine derivatives.
• Agrochemical Manufacturing: Facilitates the synthesis of complex nitrogen-containing herbicides, fungicides, and insecticides.
• Materials Science Research: Enables the construction of conjugated polymers and organic electronic materials via cross-coupling reactions.
• Academic & Industrial R&D: A preferred precatalyst for method development and scale-up studies in C–N and C–C cross-coupling reactions.
• Fine Chemical Production: Used in the synthesis of specialty chemicals, ligands, and complex organic molecules requiring robust catalytic systems.
• Process Chemistry Optimization: Valued for its stability and activity, allowing for lower catalyst loadings and milder reaction conditions in flow chemistry and continuous manufacturing.

Basic Information

Product Name	Methanesulfonato[1,1'-Bis(Diphenylphosphino)Ferrocene)](2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(II), Min. 98% [Dppf Palladacycle Gen. 3]
CAS No.	1445086-28-1
Molecular Formula	C47H41FeNO3P2PdS
Molecular Weight	924.06 g/mol
Synonyms	Dppf Palladacycle Generation 3; Buchwald Palladacycle Gen. 3; (2'-Amino-1,1'-biphenyl-2-yl)palladium(II) methanesulfonate dppf complex; Pd-PEPPSI-IPr; Palladium(II) [1,1'-Bis(diphenylphosphino)ferrocene] (2-aminobiphenyl-2'-yl) methanesulfonate; Third-Generation Buchwald Catalyst; CataCXium® PCY Gen. 3 (analogous); Air-Stable Pd Precatalyst; 1445086-28-1
EINECS	Contact for details

Quality Control

Our Dppf Palladacycle Gen. 3 is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including HPLC assay to confirm a minimum purity of 98%, alongside NMR and elemental analysis for structural verification and stoichiometric confirmation. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment. Our quality system is designed to meet the rigorous standards required for pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain long-term stability. This compound is hygroscopic (moisture-sensitive) and easily oxidized; therefore, the original container should be sealed immediately after use and stored in a cool, dry place.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 98.0%
Palladium (Pd) Content	Approx. 11.5%
Solubility	Soluble in common organic solvents (DCM, THF, toluene)
Residue on Ignition	< 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.