Description

Methanesulfonato[Di-T-Butyl(n-Butyl)Phosphine](2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(Ii) Dichloromethane is a highly specialized, air-stable palladium(II) precatalyst designed for demanding cross-coupling reactions. This compound matters because it offers a convenient, pre-activated catalyst system that simplifies handling and improves reproducibility in sensitive synthetic workflows. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex organic molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key catalyst for Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions in API development.
• Agrochemical Research: Used in the synthesis of novel active ingredients requiring C-N and C-C bond formation.
• Materials Science: Facilitates the construction of conjugated polymers and organic electronic materials via efficient coupling protocols.
• Methodology Development: Employed in academic and industrial R&D for developing new catalytic transformations under mild conditions.
• Scale-up Process Chemistry: Suitable for optimizing reaction conditions from milligram to kilogram scale due to its consistent activity.
• High-Throughput Screening: An ideal catalyst candidate for parallel synthesis and library generation in drug discovery.

Basic Information

Item	Detail
Product Name	Methanesulfonato[Di-T-Butyl(n-Butyl)Phosphine](2'-Amino-1,1'-Biphenyl-2-Yl)Palladium(Ii) Dichloromethane
CAS No.	1445086-17-8
Molecular Formula	C27H43NO3P2PdS • CH2Cl2
Molecular Weight	Contact for details
Synonyms	Palladium(II) methanesulfonate complex with Di-tert-butyl(butyl)phosphine and 2'-amino-[1,1'-biphenyl]-2-yl; [(2-Aminobiphenyl-2-yl)]Pd(MS)(DtBP); Buchwald Palladium Precatalyst G4; Pd-G4 Methanesulfonate; (2'-Amino-[1,1'-biphenyl]-2-yl)palladium(II) methanesulfonate-Di-tert-butylphosphine complex; AmPhos Pd G4 MS; Palladium, [2-(1,1-dimethylethyl)phosphinous-κP]-2-(2-aminophenyl)phenyl-C1-κC2]methanesulfonato-, (SP-4-2)-, solv. with dichloromethane
EINECS	Contact for details

Quality Control

Every batch of our palladium precatalysts is manufactured and tested under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) that include data for identity, purity, and residual solvent content, ensuring traceability and consistency for your critical research and production. Our quality systems are designed to support cGMP-compliant applications where documentation and reliability are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain long-term stability. The material is hygroscopic (moisture-sensitive) and easily oxidized; containers should be allowed to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (Pd content)	≥ 98.0% (by ICP-OES)
Purity (HPLC)	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.